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AiWon Caliburn

Device for Ablation, Controlled Laser Damage and Microdissection

The AiWon Caliburn is the third member of the AiWon series designed to induce controlled damage to biological or other samples. It features a motorized laser focus and laser power attenuator, which is completely software-controlled. Similar to the AiWon, the AiWon Caliburn produces a small laser spot in the center of the field of view. In comparison to continuous-wave lasers generally coupled via an optical fiber, the UGA‑42 Caliburn is equipped with a pulsed laser directly coupled to the system setup. Various pulsed laser light sources with a high peak power are available depending on experimental needs (e.g. at 266 nm, 355 nm, 532 nm).

Features

Modularity and Flexibility

The AiWon Caliburn can be easily combined with all other modules of the AiWon series such as the AiWon Geo selectable shape illumination device or additional ports for fiber coupled light sources. Like all devices of the AiWon series, the AiWon Caliburn can be connected to almost all models of major research microscope brands, giving you the possibility to choose the perfect microscope for your applications and individual needs. The optical setup gives you the freedom to attach the device as an add-on module to a microscope without interfering with the usage of your existing setup (e.g. spinning disk, LSM, etc.).

Applications
  •  Laser Ablation and Microdissection at 355 nm
  • DNA-Damage at 355 nm
  • Specific DNA-Damage at 266 nm
Downloads

For microscopes:
• Flyer Photomanipulation (3.5 MB)

Literature

Rüder, Marike, Benedikt M. Nagel, and Sven Bogdan. 2018. “Analysis of Cell Shape and Cell Migration of Drosophila Macrophages in Vivo.” Pp. 227–38 in Methods in Molecular Biology. Vol. 1749.

Moreira, Carolina G. A., Jennifer C. Regan, Anna Zaidman-Rémy, Antonio Jacinto, and Soren Prag. 2018. Cell Migration. Vol. 1749. edited by A. Gautreau. New York, NY: Springer New York.

Karsch, Susanne, Deqing Kong, Jörg Großhans, and Andreas Janshoff. 2017. “Single-Cell Defects Cause a Long-Range Mechanical Response in a Confluent Epithelial Cell Layer.” Biophysical Journal 113(12):2601–8.

Golia, Barbara, Giuliana Katharina Moeller, Gytis Jankevicius, Andreas Schmidt, Anna Hegele, Julia Preißer, Mai Ly Tran, Axel Imhof, and Gyula Timinszky. 2017. “ATM Induces MacroD2 Nuclear Export upon DNA Damage.” Nucleic Acids Research 45(1):244–54.

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